Cirrhoses

What are the main functions of liver in the healthy person’s body?

1. Decontamination of toxins, which enter the body from external environment.
2. Synthesis of proteins, fats, carbons.
3. Bilification.
4. Egestion of toxins from blood into intestinal tract lumina.
5. Synthesis of vital biologically active substances (albumen, blood coagulation proteins)

Liver is one of the most crucial organs in human body and responsible for multiple functions. Its average weight is 1.8 kg, which makes nearly one fifth of the adult body weight. Thanks to branched capillary network, liver permits daily passing of some two thousand liters of blood (approximately a liter and a half each minute). Liver is a main organ, which deactivates toxins arriving from ambient environment. Special enzyme systems break down bacterial exo- and endogenous toxins produced by bacteria entering the body with meal, as well as those toxin substances, which are formed in the body as a result of its vital activities.

Liver plays major role in metabolism of proteins, fats, and carbons. The most important proteins produced by liver are albumens (withholding water, they regulate circulating blood volume) and blood coagulation protein factors. Fats arriving with meal are turned in liver into lipids essential to build cell membranes, for vitamins synthesis and cell energy. Carbons, which are reserved by liver as glycogen, support body energy potential.

Bile is necessary for edible fats uptake by intestinal tract. Metabolism products harmful for the body are also produced with bile into intestinal tract lumina.

What leads to liver cirrhosis?

Physiologic liver

Hepatitis liver

Incipient stage of liver cirrhosis

End stage of liver cirrhosis

Liver is a unique organ in terms of regeneration (capability to regain destructed cells). Since liver is always under the impact of toxins, nature granted its cells with high capacity for cell division. Even after significant part of liver is removed, the organ can restore its volume and weight through division of hepatic cells and formation of new hepatocytes out of liver stem cells.

During long-term inflammatory processes (hepatitis: alcohol, toxic, virus, autoimmune), adipose degeneration (due to obesity, diabetes, or other metabolic disorders), liver loses such a capacity. Connective (scar) tissue, but not new liver cells, appears in the place of destroyed cells. Accumulation of such spots damages liver function and changes its structure (architectonics), which leads to the state called cirrhosis. Quite often, because of changes in the liver structure, patient’s immune system starts seeing own liver as a foreign organ – it produces anti-substances against liver tissue, which damage liver cells even more.

Treatment for liver cirrhosis patients is an important problem of contemporary hepatology. Even recently such a diagnosis was accepted as verdict, since life term after clinical symptoms appeared was 10-15 years as a rule. Traditional healing is aimed at pharmaceutical protection of liver cells from damage, stimulation of bile flow, and metabolism disorders correction, which improved condition of the patient, but could not stop disease progressing. In some severe cases, interplantation of liver is possible. Yet, once stem cells treatment entered clinical practice, the new hope evolved for complete cure of liver cirrhosis.

Specialists of the Institute of Cellular Therapy have vast positive experience of healing cirrhosis with own biotechnolgoies, which aim to stimulate natural recovering processes and prevent autoimmune damage of liver. This is achieved through application of regenerating potential of stem cells and Filatov tissue therapy.

It is extremely important to start stem cells treatment of cirrhosis when first symptoms of the disease appear, as it can influence the degree of liver restoration.

It is known that when stem cells enter human body, not only they can produce new tissue types, but also release biologically active substances, which stimulate division of own “adult” stem cells and thus renew cell structure of the ill organ. Stem cells get to the area of hepatic cells death, replace damaged liver cells for healthy ones, and normalize recovering processes in liver tissues. As a result of stem cells treatment of cirrhosis, one can notice significant improvement of biochemical blood indicators (albumen, bilirubin, GPT, GOT) and general condition of the patient.

As an example, we would like to demonstrate dynamics of lab based indicators of the patient, who underwent treatment in the clinic of the Institute of Cellular Therapy.

Clinical example:

Diagrams 1 and 2 present results of treatment provided to patient X, 67 y.o., with liver cirrhosis, which developed after virus hepatitis.

The patient arrived to the department of liver pathologies of the medical institution in extreme emergency: confusional conscience, frank biliousness of scleras and skin, massive edemas, abdominal dropsy. Standard therapy with multiple application of apparatus blood clearance had low effect. The patient was transferred to the Institute of Cellular Therapy, where he received stem cells treatment according to authorial methodology.

As a result of 10-days treatment, complete remission was achieved, and the patient was released in satisfactory condition (no abdominal dropsy, edemas, or biliousness). Diagram 1 shows dynamics of whole protein and albumen content changes in blood: after application of stem cells and Filatov tissue therapy both indicators grew to normal values. It means that a very important function of liver – protein synthesis – has been restored.

Diagram 1

Diagram 2

Diagram 2 demonstrates dynamics of whole, direct, and indirect bilirubin content in blood. Bilirubin accumulation in blood leads to biliousness and damages function of brain and kidneys. As a result of stem cells application and Filatov tissue therapy, content of whole, direct, and indirect bilirubin in blood plasma decreased to normal values.

Hence, clinical experience of specialists from the Institute of Cellular Therapy proves that cirrhosis treatment with stem cells leads to fast recovery of liver functions and its regeneration.