Pancreatonecrosis post-operational

Pancreatitis – inflammation of pancreatic glands. In case of pancreatitis ferments, releasing by glands, don not get into dodecadactylon, but are activated in gland and start to destroy it (self-digestion (). Ferments and toxins, being released, can get into blood flow and seriously damage other organs, such as heart, kidneys and liver. Acute pancreatitis – very severe condition of organism, which requires immediate treatment in a hospital under the supervision of doctors.

There is acute, chronic and reactive pancreatitis. Acute pancreatitis has following types: edematous form of acute pancreatitis, hemorrhagic pancreatolysis, fatty pancreatolysis. Chronic pancreatitis can have pseudocystic form, fibrous form, pseu-dotumor-like pancreatitis.

The most frequent reasons of pancreatitis - gallstone disease and alcoholic consumption combined with plentiful ingestion. Also pancreatitis can be caused by toxication, injuries, virus diseases, operations and endoscopic manipulations. Big doses of vitamins А and Е (these vitamins are contained in preparatus Aevit) can also cause the recrudescence of acute pancreatitis.

Acute pancreatitis, especially complicated by necrosis (death) of pancreatic glands part, can be treated by means of surgical methods. The main problem of such treatment – frequent surgical complications, which can be resulted in death of patient (80% of cases) or can cause chronization of pathological process with appearance of true or false cysts.

Institute of cellular therapy in association with specialists from the Coordination center of organs, cells and tissues transplantation of the Ministry of Health protection of Ukraine and surgeons from National academy of postgraduate education named after P.L. Shupik has worked out methodology of complex treatment of pancreatic glands necrosis using cords and transplantation of umbilical blood stem cells. The principle of method – after usual surgical measures specially prepared cryoconserved tissue of umbilical cord is implanted to the zone of necrosis, this cord contains bioactive substances, aiding obliteration of gaping pancreatic ducts. It can prevent cystogenesis (formation of cysts). Implant is removed through drain stoma in a two days after operation, and at the same time stem cells of umbilical blood are transplanted to patient in a small doses. Transplantion of cells is repeated every day during 5-7 days. Results of transplantation – achieved effect of stimulation of reparative regeneration processes, post-operation injuries skin over with primary intention, terms of post-operational hospital stay of patient are decreased.

Clinical example. Abovementioned methodology of treatment was applied to more than 20 patients. Mortality was not observed, cysts were not found during 6 months after surgery. One of patients, who did not participate in abovementioned group of treatment, after usual surgery had developed respiratory distress syndrome with decrement of saturation to 50%. At reanimation department there was carried out 5-hold (one time per day) transplantation of umbilical blood stem cells. As a result, respiratory function and respiratory-perfusion correlation was renewed, patient was signed out without any complications in 10 days after first transplantation of umbilical blood stem cells.