Nicoloz is an 8-year-old boy from Georgia. Parents of Nikoloz preserved his umbilical cord blood in the cord blood bank in Tbilisi. They had no particular reasons to store the baby’s umbilical cord blood, but they really trusted the obstetrician who advised them to do this. After 2 years, parents noticed that something was wrong with the baby, the child often presented emotional explosions but did not say a single word, was unable to concentrate attention, did not communicate with other children and showed no interest to them. At the age of 3 years the child was diagnosed with autism.
Autistic spectrum disorders are neurodevelopmental disturbances, manifesting at an early age.
Typical manifestations of autism are violations of social interaction, repetitive behavior, limited interests and activity.
The causes of autism are diverse: from genetic predisposition to environmental factors. Some changes in the morphology of the brain of autistic patients have been scientifically proven. Drugs or other therapies of this disease do not exist.
If earlier autistic spectrum disorders were diagnosed in 1 to 88 children, nowadays in 1 to 68. Treatment and education of children with autism are quite expensive. About 40% of children with autism suffer from mental retardation.
When Nicoloz was diagnosed with autism, the boy was administered Applied Behavior Analysis (ABA), an intensive program, designed to teach children with autism basic social skills from the ability to communicate to social interactions, self-care, behavioring in school, getting employed in the future.
But, unfortunately, AVA-therapy provided only slight improvement of Nicoloz’ condition, he could correctly pronounce only 3 words. In 2016, parents of Nicoloz learned from TV that the use of own cord blood reduces the manifestations of autism. They contacted the umbilical cord blood bank, where they were provided information about the clinical trial on autism treatment by the cord blood stem cells in Georgia.
This study implicates 3 intrathecal injections of the own cord blood stem cells to children with autism, with 6-month intervals.
During intrathecal injection, the needle is inserted between the vertebrae, delivering the stem cells directly to the cerebrospinal fluid, which in turn carries them to any part of the cerebral cortex, cerebellum, and limbic system. Thus, transplanted stem cells reach the foci of injury, providing a more pronounced paracrine effect. When administered intravenously, most stem cells are filtered from the blood by the lungs, spleen, liver, and only the remaining cells reach the hematoencephalic barrier. Namely, the amount of stem cells reaching the brain is critical for the effectiveness of cell therapy. Luckily, Nicoloz’ umbilical cord blood was stored in 4 containers, allowing the multiple use of stem cells. The Ukraine’s first Cryobank of the Institute of Cell Therapy also stores umbilical cord blood in cryocontainers, that gives opportunity of the multiple application of frozen stem cells.
Actually it has been proven that for the treatment of autism, the required dose of nucleated cells of the umbilical cord blood is 68 million nucleated cells per injection. Nicoloz showed a significant improvement after 2 injections. His vocabulary has expanded significantly, now the child can pronounce almost every word, and even communicate with short sentences. His behavior has also improved, and now the child is not so aggressive, emotional explosions are no longer noticed. To date, Nicoloz attends school and studies according to only a slightly adapted program. Parents of Nicoloz have always taken the most active part in the treatment and training of their son. They regard the improvement in their child to a kind of miracle.