How stem cells combat coronavirus

The article, published in the scientific journal Aging and Disease (2020) states that mesenchymal stem cells are a safe and effective approach to COVID-19 treatment (https://documentcloud.adobe.com/link/track?uri=urn% 3Aaaid% 3Ascds% 3AUS% 3A92914ceb-75b4-41e4-a7d8-21f2fcf29cc8). At least 10 projects have been registered in the official international registry for clinical trials, implicating the use of mesenchymal stem cells to patients with coronavirus pneumonia (https://clinicaltrials.gov/ct2/results?cond=covid+19&term=stem+cells&cntry=ccry=&cry & dist =).

After the first successful case of overcoming COVID-19 in a 65-year-old woman in ICU, who on day 3 after the introduction of mesenchymal stem cells of the umbilical cord started walking, the scientists used these cells in another 7 patients.

Today, there are official data on the recovery of at least 7 patients with COVID-19 courtesy of mesenchymal stem cell treatment. All patients had fever, shortness of breath, decreased oxygen saturation, pneumonia.

  • Patients received mesenchymal stem cells at a dose of 1 million per kg of body weight.
  • Almost all manifestations of the disease began to decrease after 2-4 days.
  • No side effects of cell therapy were observed.
  • Computed tomography of the chest showed a significant decrease in the degree of pneumonia.
  • After 1-2 weeks, the COVID-19 test was negative in all patients.

How does COVID-19 affect the immune system?

COVID-19 causes a cytokine storm in the body, that is, virus-activated immune cells secrete an excess of cellular hormones (cytokines) that have damaging effects on their own tissues, promote swelling, fibrosis (growth of connective tissue) and functional insufficiency.

How do mesenchymal stem cells help with COVID-19?

Mesenchymal stem cells are a powerful immunomodulatory and anti-inflammatory agent, they normalize the function of the immune system, altered by COVID-19. The anti-inflammatory effect of mesenchymal stem cells has been known for a long time, that is why they have been successfully used for over 10 years in the treatment of autoimmune diseases (rheumatoid arthritis, ulcerative colitis, multiple sclerosis) and for the inhibition of transplanted organs rejection.

Mesenchymal stem cells in COVID-19

  • Increase the number of lymphocytes and regulatory dendritic cells, that is, increase their own antiviral protection.
  • Reduce the level of C-reactive protein, which is a major marker of inflammation.
  • Reduce the level of such a powerful pro-inflammatory protein as TNF-a.
  • Increase the level of anti-inflammatory protein IL-10.

According to the Kyoto Encyclopedia of Genes and Genome, mesenchymal stem cells directly take part in antiviral protection.

Positive effect of mesenchymal stem cells is observed even in old age.

Source: https://documentcloud.adobe.com/link/track?uri=urn%3Aaaid%3Ascds%3AUS%3A92914ceb-75b4-41e4-a7d8-21f2fcf29cc8, https://clinicaltrials.gov/ct2/results?cond = covid + 19 & term = stem + cells & cntry = & state = & city = & dist =, https://documentcloud.adobe.com/link/track?uri=urn%3Aaaid%3Ascds%3AUS%3Ae290bfcb-44d0-4e6c-8f3b-99e9fb1clid=f IwAR1dYwEIAqjffKBM31DXnrdUt2NF9iHVaFwjp4aHj1ZXPd2YxOrrS79eDMg

The Institute of Cell Therapy has developed a program to increase the body’s antiviral protection using mesenchymal stem cells of the umbilical cord and placenta. Ukraine’s only ISO-accredited Cryobank, which has been successfully operating at the Institute of Cell Therapy since 2003, has successfully provided stem cell preparations to state medical institutions of Ukraine for over 10 years. The specialists of the Institute of Cell Therapy have many years of working experience with mesenchymal stem cells, their cultivation and cryopreservation.

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