Andrii Shevchenko about own experience of stem cell treatment in the Institute of Cell Therapy Clinic

December 3rd, the press-conference on the topic “Medicine of the future: Cell Technologies in Ukraine. How to score a decisive penalty to the disease? A football player Andrii Shevchenko tells own experience of stem cell treatment” was held in the Institute of Cell Therapy in Kiev. 

At this medical event were presented the first results of the clinical trials on placental stem cells in Ukraine, carried out in partnership with the Institute of Traumatology and Orthopedics of NAMS of Ukraine and Kiev Clinical Hospital №6. This time the specialists focused their attention on such wide spread diseases as knee joints arthrosis and joints injuries, in particular in professional athletes. Andrii Shevchenko, a legendary football-player and trainer of the national team of Ukraine participated in the press-conference.

“After finishing the football carreer the knee joint began to inflame, pain appeared. It was hard to fight with that. The advanced technologies did not give any relief. In America I have heard about the new technology. In Kiev I got acquainted with the Institute of Cell Therapy specialists, they told about this therapy.  After the treatment I felt myself much better. The joints have better tolerance towards loading. It’s nice that Ukraine owns technologies, that are competitive with the world level” said Andrii Shevchenko.  

Osteoarthrosis is one of the most prevalent diseases worldwide, that occurs in most people over 60 years of age. This is a joint inflammation, when the destruction of joint cartilagos occur. These are the knee joints that get affected in both females and males with age, especially if overweight, and this type of osteoarthrosis is called gonarthrosis. The development of gonarthrosis is facilitatted by different traumas, in particular sports traumas, heredity, hypodynamia and different systemic diseases.

Despite the numerous methods of osteoarthrosis treatment, from antiinflammatory drugs, pain-killers, chondroprotectors, physiotherapy to surgical prosthetics of the damaged joint, none of these methods can restore the damaged cartilago. However, there is an increasing number of reports  in recent years  that damaged cartilagos may be restored by the stem cells, providing patients with osteoarthrosis a new life quality. 

In Ukraine, the Institute of Cell Therapy Clinic in partnership with the Institute of Traumatology and Orthopedics of NAMS of Ukraine and Kiev Clinical Hospital №6 developed an innovative therapy for gonarthrosis, based on placental stem cells application. Coordination Centre of Transplantation of Organs, Tissues and Cells of the Ministry of Health of Ukraine issued the permission for the perfomance of clinical trials, in the framework of which placental stem cells are already used for the treatment of knee joints arthrosis and joints damages, in particular in professional athletes. Isolation and cryconservation of placental stem cells for all patients is performed by the Institute of Cell Therapy Cryobank. 

In the press-conference participated:

Andrii Shevchenko a legendary athlete and chief trainer of the national football team, noted that the level of cell therapy in Ukraine complies to world standards, acknowledged that stem cell therapy is especially important for professional athletes and said that he was proud of the level of medicine development in his native country as well as recommends this therapy to his close ones and collegues.  

Mykola Sokolov MD,  PhD,  Chief Doctor of the Institute of Cell Therapy, leading specialist in cell technologies, told about half a century long experience of the Institute of Cell Therapy professionals in the field of work with stem cells and attracted attention to the importance of cell technologies development in Ukraine. 

Volodymyr Shablii PhD, Deputy CEO of the Stem Cells Bank, Chief of the Laboratory for Placenta Stem Cells of the Institute of Cell Therapy, member of the International Placenta Stem Cell Society, told in detailes about cell drugs manufacturing process, unique properties of the placenta and the conditions, in which the biomaterial is stored. As Dr. Shablii noted, the cryoconserved placental cells, obtained in the laboratory of the Cord Blood Bank of the Institute of Cell Therapy, were used in this study. According to the legislation, placenta is delivered to the laboratory, tested towards lack of infectious agents and after some time of cultivation a ready product is obtained, that is the cryoconserved mesenchymal placental stem cell drug, frozen in the special cryoenvironment  and stored in liquid nitrogen at temperature minus 196 C in the Institute of Cell Therapy Cryobank.  Upon physician’s request, these cells are delivered to Clinic, where they are defrosted and introduced by a medical professional into the affected joint. 

Ievgen Golyuk MD, PhD, Chief of the Scientific and Practical Centre of Tissue and Cell Therapy of the state institution “Institute of Traumatology and Orthopedics of the National Academy of Medical Sciences of Ukraine” focused attention on the use of stem cells as an effective tool for the treatment of musculo-skeletal system pathology, that allows to improve the quality of life of a patient, suffering from osteoarthrosis and significantly postpones (for years) or even cancels at all the need for the replacement of the own joint by the artificial one. 

Roman Birsa MD, a physician of the highest qualification category, orthopedist-traumatologist of the Department of Traumatology and Orthopedics, Kiev City Clinical Hospital №6, marked that traumas both in big and small sport is a very common case. These are weightlifters, mountain skiers, hockey and football players, who get injurised the most frequently (however, anybody may get joint injury anywhere), their joints are exposed to the hardest loadings. Dislocations, strainings, fractures, hits – all of this slowly leads to degenerative and dystrophical changes in joints in the form of knee arthrosis. This disease is accompanied by the severe pain, limitations during walk or sometimes by total inability to move. It is possible to inhibit the development of degenerative changes in cartilaginous tissue with the help of cell therapy, an innovative, extremely promising method of diseases and traumas treatment, allowing to restore damaged tissues of the organism with the help of stem cells transplant.  

Petro Nemtinov MD, PhD, a senior researcher of the Coordination Centre of Transplantation of Organs, Tissues and Cells of the Ministry of Health of Ukraine, outlined that this clinical trial is carried out in accordance with the Order of the Ministry of Health of Ukraine from October 10th 2007 № 630 „On Approval of the Order of Tissue and Cell Transplants Clinical Trials….registered in the Ministry of Justice of Ukraine on October 25th 2007 according to № 1206/14473”. The patients may participate in the clinical trial only after signing the informed consent of the clinical trial participant. 

The result of the clinical trials, conducted by the Institute of Cell Therapy in the partnership with the Institute of Traumatology and Orthopedics of NAMS of Ukraine and Kiev Clinical Hospital №6 should become the opportunity to use cell therapy for knee arthrosis treatment, improve of the life quality of the patients, suffering from this pathology as well as to avoid or postpone the surgery on knee joint replacement by the artificial one.

Institute of Cell Therapy is a hightechnological and innovative medical institution, specializing on research, medical services and has the own Centre of Science with a Laboratory for Placenta Stem Cells, Cryobank for the storage of the umbilical cord and placental stem cells, Cell Therapy Clinic. It should be noted that this is not the first time that the Institute of Cell Therapy carries out clinical trials, confirming the safety and effectiveness of cell and tissue preparations in different disorders.  Courtesy of these projects the positive image of cell and tissue therapy in Ukraine, launched yet in the beginning of 20th century by the academician Filatov gets facilitated. The Coordination Centre for Transplantation of Organs, Tissues and Cells of the Ministry of Health of Ukraine issued a permission for the use of tested technology of manufacturing and application  of cell/tissue drugs for the treatment of pancreonecrosis and disorders of peripheral arteries of the lower limbs using the umbilical cord blood and autologous adipose tissue stem cells. Today 4 clinical trials on the use of cell and tissue therapy methods are on the final stage and other 4 trials are going on. 

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