Diabetes mellitus type 2

Diabetes mellitus type 2 is a chronic endocrine disorder, characterized by disregulation of blood sugar level and lack of the normal “perception” of insulin in organs and tissues of the body. Patients with diabetes mellitus type 2 make about 90% of the total number of cases of diabetes mellitus.

Diabetes is ranked as the third in the world after cardiovascular diseases and cancer. According to various sources, there are from 120 to 180 millions people, suffering from diabetes mellitus in the world, accounting for 2-3% of the world’s population. The prevalence of diabetes has acquired a character of so-called non-infectious epidemics.

In most cases, diabetes mellitus type 2 is a hereditary disease. The incidence of diabetes has a family character, and your risk is 40%, if your close relatives suffered from this disease. The likelihood of the development of diabetes mellitus is 50%, if the father had diabetes, and 35%, if the mother was sick.

The main symptoms of the diabetes mellitus type 2 are excessive thirst, excessive urination, weakness, fatigue and dry mucous membranes. In type 2 diabetes, the progressive increase of the blood glucose level and reduced ability to capture glucose by tissues occur, whereby the body utilizes free fatty acids and amino acids as the sources of energy, but the latter are necessary for the body for other purposes. Obesity is also observed in the majority of patients with diabetes mellitus type 2.

One of the most common complications of diabetes mellitus are cardiovascular diseases, renal disease and retinal eye disease (retinopathy). Approximately 65% of deaths from diabetes mellitus are due to the myocardial infarction or stroke. Chronic hyperglycemia leads to the increase of the osmotic pressure of blood and damage of the vessel wall (angiopathy). In diabetic micro-and macroangiopathy the vascular permeability is disrupted, vessel fragility is increased and the tendency to thrombosis and atherosclerosis occurs. Renal disease in diabetes (diabetic nephropathy) is one of the factors of the development of chronic renal failure. Diabetic retinopathy is a common cause of blindness in older people. Diabetes mellitus is another dangerous complication of the so-called “diabetic foot”. Violation of the microvasculature and secondary immunodeficiency cause the infections of the soft tissues of the foot, nonhealing wounds, trophic ulcers. These patients develop necrotic processes of the ulcerated foot, lesions of bones and joints. The diabetic foot often leads to the necessity of the limb amputation in diabetic patients.

Treatment. Due to the multiple life-threatening complications of the disease, diabetes mellitus is an extremely important medical and social problem.

For the treatment of diabetes mellitus type 2 the medicines, capable to reduce the level of blood sugar and insulin, are applied. The secondary complications of the disease should also be managed. However, the currently known methods of correction of metabolic disturbances in diabetes mellitus do not provide the desired effect and do not prevent disability.

Therefore, immunobiological methods of cell and regenerative therapies are increasingly used in the treatment of diabetes mellitus and its complications in the leading medical centers around the world. For this purpose the cultures of xenogeneic cells from Langerhans islets were investigated, as well as bone marrow and cord blood stem cells. American scientists have shown a positive effect of the umbilical cord blood infusions in patients with diabetes mellitus, enabling to reduce the dose of insulin in such patients. Also it was shown that the use of endothelial progenitor cells, capable to form new blood vessels, promotes neangiogenesis in patients with obliterative vascular disease of the lower extremities on the background of diabetes mellitus type 2.

The Institute of Cell Therapy developed and clinically tested the method of treatment of diabetes mellitus, the 1st and 2nd type, by means of hematopoietic stem cells transplantation. The main purpose of such treatment is the prevention of complications of diabetes mellitus, normalization of the level of glycosylated hemoglobin in blood, reduction of the dose of insulin in diabetes type 1, and the normalization of blood glucose level in diabetes type 2. The principle of treatment is based on the fact that the hematopoietic cells are able to transform into β-cells in the pancreas as well as to stimulate the formation of these cells from the patient’s own stem cells (such cells are present in pancreatic ducts). Furthermore, hematopoietic cells restore the endothelial cells of blood vessels, that are damaged by glycosylated hemoglobin in diabetes mellitus. It is noteworthy, that the transplantation of the large doses of hematopoietic stem cells eliminates the autoimmune component of the disease in patients with diabetes mellitus type 1 and 2.

The Institute of Cell Therapy together with the Institute of Endocrinology and Metabolism n.a. V.P. Komisarenko of
NAMN of Ukraine also developed the methods of treatment of diabetes mellitus and its compications using cryoconserved nucleated cells of umbilical cord blood, cryoconserved multipotent stromal cells of the placenta as well as cryoconserved amniotic membrane. Based on the positive results of precinical studies the Institute of Cell Therapy in cooperation with the Institute of Endocrinology and Metabolism n.a. V.P. Komisarenko of NAMN of Ukraine developed and submitted for the review of the Coordination Centre of Transplantation of the Ministry of Health of Ukraine the project of the clinical trial “Efficacy of the Use of Nucleated Cord Blood Cells, Cryoconserved Multipotent Stromal Cells of the Placenta and Cryoconserved Amniotic Membrane Separately and in Combination in the Treatment of Diabetic Neuropathy, Peripheral Arteries Damage and Trophic Ulcers of Lower Limbs”.

Clinical example. As an example, the data on the treatment of 25 patients with diabetes mellitus type 2, who participated in the clinical trials on the hematopoietic stem cell transplantation, performed by the Coordination Centre on Organs, Tissues and Cells Transplantation of the Ministry of Health of Ukraine on the basis of the Institute of Cell Therapy. The diagrams clearly show that within 3 months after transplantation the level of glucose and glucosylated hemoglobin reduced almost to normal values and remain stable for 1 year. In addition, in these patients the indices of fat metabolism also were normalized, the atherogenic index decreased, the biochemical parameters of liver function improved. All patients also noted the improvement of the quality of life.

Dynamics of the content of glucose and glucosylated hemoglobin in blood plasma after hematopoietic stem cell transplantation

Treatment of diabetes mellitus type 2 with the use of stem cells does not only increase the effectiveness of treatment by traditional means and methods, but sometimes enables to refuse completely from them. Stem cells restore sensitivity of cells and tissues to the action of insulin, significantly improve pancreatic function, which leads to the normalization of blood sugar level. If you suffer from diabetes mellitus type 2, we invite you to our clinic for a high quality and effective treatment of this disease.

Stem cells are injected intravenously. The principle of treatment is based on the fact that stem cells are able to transform into β-cells of the pancreas and promote the formation of stem cells of the patient. This can result not only the restoration of the normal level of sugar in blood but also anables to prevent the complications of diabetes mellitus, such as the damage of blood vessels of the retina, kidney, heart and legs.

You will feel the effect during 2-3 months after administration of stem cells. Clinical tests confirm that after stem cell treatment the positive tendency towards the increase of the level of insulin and decrease of the blood sugar. This therapy also causes the healing of the ulcers and tissue defects of the foot, improves microcirculation and reduces the incidence of diabetic angiopathy. Also the recovery of “red blood” occurs, namely the increase of the level of hemoglobin and number of red blood cells.

Do not waste your time and contact us, because the sooner you apply for this method, the more effective the treatment will be. For expert advice regarding diseases, complete the simple form on the right.

 

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